By Donald J. Hanahan
This publication presents a concise advent to phospholipid chemistry and is meant for a huge viewers of biologists, biochemists, and graduate scholars. constructed as a part of a graduate direction on lipids, this booklet additionally serves as a reference for laboratory investigators on sign transduction and organic membranes. the 1st a part of the textual content is dedicated to an orientation to the chemical nature of lipids commonly, how they're considered linked within the mobilephone, and the method during which the mobile lipids (including the phospholipids) may be recovered from cells and subjected to an preliminary identity. next chapters signify the choline-containing phospholipids, together with the sphingolipids, the non-choline containing phospholipids, and eventually, the so-called minor phospholipids. The latter compounds, which act as agonists or lipid chemical mediators on cells, shape a forefront of a brand new classification of biologically energetic components and feature set the learn of mobile phospholipids on a brand new and exiting path. most significantly, this ebook presents a foundation for extra inquiry on those complex molecules, displaying that even supposing the compounds are targeted, with care and knowing, they are often studied conveniently
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Additional info for A Guide to Phospholipid Chemistry
However, it should be noted that at the time of the report in the 1940s on phosphatidic acid in cabbage, enzymology was still a field in its infancy, and certainly any proposal that an enzyme could be activated by an organic solvent would have met with much disfavor or more likely disbelief. Notwithstanding the historical facets of these observations, ethanol-ether mixtures have been replaced by a much more efficient and reliable system. Undoubtedly, the most widely employed solvent system in use today is that of chloroform and methanol.
If you need to justify the choice of human platelets as the cell of choice, a number of highly creditable reasons can be cited. Only three need to be considered at this point. First, the circulating platelet is of paramount importance in hemostasis, and there is convincing evidence that its membrane phospholipids are intimately involved in this process. Second, these cells can serve as excellent targets or model systems for stimulus-induced activation in which the membrane phospholipids play an important role.
Primarily, as mentioned earlier it appears to be a bonding involving water molecules, principally through hydrogen bonding, though aliphatic hydrocarbons can play a role. The support for noncovalent interaction and the role of water is that neutral solvents such as ethanol or methanol are very effective in breaking this interaction of lipid to protein. However, if one chooses to use diethyl ether alone or chloroform alone, this will allow a poor recovery of lipid from cells or tissue, at least at room temperature.
A Guide to Phospholipid Chemistry by Donald J. Hanahan